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中科院青促会会员

任锦启  博士 副研究员  

中国科学院青年创新促进会会员
中科院生物物理所,生物大分子国家重点实验室

研究方向:驱动蛋白介导的细胞内货物运输

电子邮件:jinqi@ibp.ac.cn

电       话:010-64888853

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_zkyqchhy/202302/t20230202_339555.html

简       历:

  2006.09 - 2010.06  山西大学,理学学士

  2010.09 - 2015.06  中国科学院大学,理学博士

  2015.07 - 2018.12  中国科学院最新beat365下载,助理研究员

  2019.01 - 至今        中国科学院最新beat365下载,副研究员

获奖及荣誉:

社会任职:

研究方向:

  驱动蛋白是细胞内定向运输系统的关键分子马达。我们的研究围绕驱动蛋白如何进行活性调控、如何识别货物等科学问题展开。通过对参与调控细胞内定向货物运输的驱动蛋白进行结构与功能研究,希望可以阐明驱动蛋白调控细胞内定向货物运输的一些基本规律。

承担项目情况:

  1. 中国科学院稳定支持基础研究领域青年团队计划(YSBR-075),2022-2027,参加

  2. 科技创新2030"脑科学与类脑研究"重大项目(2022ZD0205800),2022-2027,参加

  3. 国家自然科学基金面上项目(31971160),2020.01-2023.12,59万元,主持

  4. 国家自然科学基金青年基金项目(31600608),2017.01-2019.12,21万元,主持

代表论著:

1. Wang, W.J.#, Ren, J.Q.#, Song, W.Y.#, Zhang, Y., Feng, W.* (2022) The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for auto inhibition. Nature Communications, 13,4281

2.Ren, J.Q.#, Li, D.#, Liu, J.Y.#, Liu, H., Yan, X.M., Zhu, X.L.*, Feng, W.* (2022) Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Reports, 41,111589

3. Cong, D.Z.#, Ren, J.Q.#, Zhou Y.R., Wang, S., Liang J.J., Ding, M.*, Feng, W.* (2021) Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. PLOS Genetics, 17,e1009940

4.Ren, J.Q.#, Liang, R.B.#, Wang, W.J.#, Zhang, D.C., Yu, L., and Feng, W.* (2020). Multi-site-mediated entwining of the linear WIR-motif around WIPI p-propellers for autophagy. Nature Communications, 11, 2702

5. Liang, R.B.#, Ren, J.Q.#, Zhang, Y., and Feng, W.* (2019). Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. Journal of Molecular Biology, 431, 1494-1505.

6. Xu, Y.#, Ren, J.Q.#, He, X.#, Chen, H., Wei, T.*, and Feng, W.* (2019). YWHA/14-3-3 proteins recognize phosphorylated TFEB by a non-canonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 1017-1030.

7.Ren, J.Q.#, Wang, S.#, Chen, H., Wang, W.J., Huo, L., and Feng, W.* (2018). Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. PNAS, 115, E11933-E11942.

8.Ren, J.Q.#, Zhang, Y.#, Wang, S.#, Huo, L., Lou, J., and Feng, W. (2018) Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. Journal of Molecular Biology, 430, 2030-2041

9.Ren, J. Q.#, Huo, L.#, Wang, W. J., Zhang, Y., Li, W., Lou, J. Z., Xu, T., and Feng, W. . (2016) Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. The Journal of Biological Chemistry, 291, 3581-3594

10. Ren, J. Q., Feng, L., Bai, Y. J., Pei, H. H., Yuan, Z. Q., and Feng, W.* (2015) Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. Biochemical Journal, 468, 133-144

(资料来源:任锦启副研究员,2023-02-02)