当前位置 首页 科研队伍

中科院青促会会员

时颖超(已调离)  博士 副研究员  

中国科学院青年创新促进会会员
中科院生物物理所, 脑与认知国家重点实验室

研究方向:大脑皮层和神经环路发育

电子邮件:shiyingchao@ibp.ac.cn

电       话:010-64888125

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_zkyqchhy/202204/t20220408_339561.html

简       历:

  2007.09 - 2011.06  山东师范大学,理学学士

  2011.09 - 2014.06  山东师范大学,理学硕士

  2014.09 - 2018.06  中国科学院大学,理学博士

  2018.09 - 2021.12  中国科学院最新beat365下载,助理研究员

  2022.01 - 2022.10  中国科学院最新beat365下载,副研究员

获奖及荣誉:

社会任职:

研究方向:

  1. 人脑中间神经元多样性形成的分子和细胞机制  

  中间神经元是大脑皮层中除兴奋性锥体神经元之外的另一类重要的神经元类型,其对于神经环路建立及脑功能调控是必不可少的。中间神经元在形态、基因表达、环路连接及电生理活动等方面的多样性是大脑实现复杂而精细功能的基础。

  2. 三维类脑器官培养技术的开发及应用  

  类脑器官是在体外培养的具有与人脑类似结构的三维神经组织,能够很好地模拟神经发生,神经元迁移,皮层分层及神经环路建立等体内过程。另外,得益于病人iPSCs的可获取性,类脑器官被广泛应用于揭示神经系统疾病的发病机制。

承担项目情况:

代表论著:

1. Yingchao Shi; Mengdi wang; Da Mi; Tian Lu; Bosong Wang; Hao Dong; Suijuan Zhong; Youqiao chen; Le Sun; Xin Zhou; Qiang Ma; Zeyuan Liu; Wei Wang; Junjing Zhang; Qian Wu; Oscar Marin; Xiao qun Wang; Mouse and human share conserved transcriptional programs for interneuron development, Science, 2021, 374(6573): eabj6641

2. Yingchao Shi; Le Sun; Mengdi Wang; Jianwei Liu; Suijuan Zhong; Rui Li; Peng Li; Lijie Guo; Ai Fang; Ruiguo Chen; Woo-Ping Ge; Qian Wu; Xiaoqun Wang; Vascularized human cortical organoid s (vOrganoids) model cortical development in vivo, PLOS Biology, 2020, 18(5): e3000705

3. Yingchao Shi; Qian Wu; Xiaoqun Wang; Modeling brain development and diseases with human cerebral organoids, Current Opinion in Neurobiology, 2021, 66: 103-115

4. Yingchao Shi; Shihua Li; Qian Wu; Le Sun; Junjing Zhang; Na Pan; Qihui Wang; Yuhai Bi; Ji ng An; Xuancheng Lu; George Fu Gao; Xiaoqun Wang; Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring, Scientific Reports, 2018, 8(1): 3541

5. Zhihui Liu; Zijun Chen; Congping Shang; Fei Yan; Yingchao Shi; Jiajing Zhang; Baole Qu; H ailin Han; Yanying Wang; Dapeng Li; Thomas C. Sudhof; Peng Cao; IGF1-Dependent Synaptic Plastici ty of Mitral Cells in Olfactory Memory during Social Learning, Neuron, 2017, 95(1): 106-122

6. Congping Shang; Zhihui Liu; Zijun Chen; Yingchao Shi; Qian Wang; Su Liu; Dapeng Li; Peng Cao; A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice, Science, 2015, 348(6242): 1472-1477

7. Xin Zhou; Yufeng Lu; Fangqi Zhao; Ji Dong; Wenji Ma; Suijuan Zhong; Mengdi Wang; Bosong W ang; Yuqing Zhao; Yingchao Shi; Qiang Ma; Tian Lu; Jun Zhang; Xiaoqun Wang; Qian Wu; Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development, Cell Stem Cell, 2022, 29(2): 328-343

8. 王晓群; 吴倩; 时颖超; 一种纹状体类器官的制备方法和应用, 2020-1-20, 中国, 202010062009.0 (专利)

(资料来源:时颖超副研究员,2022-04-08)