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中科院青促会会员

宋婀莉(已调离)  博士 研究员  

中国科学院青年创新促进会会员
中国科学院"卢嘉锡青年人才奖"获得者
中国科学院生物物理所,生物大分子国家重点实验室

研究方向:胰岛素分泌的分子机制

电子邮件:songali@ibp.ac.cn

电       话:010-64888522

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_zkyqchhy/202005/t20200519_339619.html

简       历:

  1999.09 - 2003.07  北京师范大学生命科学学院,生物科学,学士

  2003.08 - 2007.06  北京协和医学院基础医学院/中国医学科学院基础医学研究所,病理学与病理生理学,博士

  2007.07 - 2010.08  中国科学院最新beat365下载,助理研究员

  2010.09 - 2020.11  中国科学院最新beat365下载,副研究员

  (2014.05 - 2015.04  哈佛医学院/波士顿儿童医院,Visiting Scientist)

  (2015.05 - 2015.09  哈佛医学院/波士顿儿童医院,Research Associate)

  2020.12 - 2022.06  中国科学院最新beat365下载,研究员

获奖及荣誉:

  2009年  北京协和医学院/中国医学科学院优秀博士论文

  2010年  中国科学院卢嘉锡青年人才奖

社会任职:

研究方向:

  糖尿病是危害人类生命健康的一种重大代谢性疾病,我国是世界糖尿病第一大国,已成为我国公共健康面临的最大挑战之一。我们团队围绕胰岛素分泌的分子机制开展了系统的研究,近期主要以机体中分泌胰岛素的胰岛器官为研究对象,通过建立和利用胰岛类器官模型,研究人类胰腺的发育机制和糖尿病的发病机制。具体研究内容包括:

  1. 胰岛素囊泡转运和分泌的分子机制。以多个关键调控蛋白为切入点,利用生化和分子生物学、细胞生物学、蛋白质组学、基因编辑、活细胞超分辨成像、干细胞和类器官、动物模型等手段,研究胰岛素囊泡在胰岛beta细胞中生成和成熟、转运和分泌、以及内吞和再循环过程的分子机制。

  2. 胰岛类器官模型的建立和应用。利用干细胞、基因编辑、生物材料等多种技术,发展胰岛类器官的诱导方法,获得结构和功能更成熟的胰岛类器官模型;并应用该模型,研究胰岛的发育、组成和功能,以及糖尿病相关基因异常造成胰岛发育缺陷和功能障碍的分子机制及其导致糖尿病的致病机制。

承担项目情况:

代表论著:

#(共)第一作者,*(共)通讯作者;按时间倒序排列

1. Linlin Wang, Hongyang Liu, Xiaofei Zhang, Eli Song, You Wang, Tao Xu*, Zonghong Li*, Wolfram syndrome 1 (WFS1) as a receptor mediates ER export of vesicular cargo proteins in pancreatic β-cells, Nature Communications. 2021 Nov 30;12(1):6996.

2. Xiaofei Zhang#, Zhuo Ma#, Eli Song*, Tao Xu*, Islet organoid as a promising model for diabetes, Protein Cell. 2021 Mar 10:1-19.

3. Zhuo Ma#, Md. Nur Islam#, Tao Xu, Eli Song*, AP-3 mediated vesicle trafficking and disease, Biophysics Reports. 2021; 7(2): 91-100.  (Cover story)

4. Yinsuo Zhao, Eli Song, Wenjuan Wang, Chung-Han Hsieh, Xinnan Wang, Wei Feng*, Xiangming Wang*, Kang Shen*, Metaxins are core components of mitochondria transport adaptor complexes, Nature Communications. 2021 Jan 4;12(1):83.

5. Maika S. Deffieu#,*, Ieva Cesonyte, Francois Delalande, Gaelle Boncompain, Cristina Dorobantu, Eli Song, Vincent Lucansky, Aurélie Hirschler, Sarah Cianferani, Franck Perez, Christine Carapito, Raphael Gaudin*, Rab7-harboring vesicles are carriers of the Transferrin Receptor through the biosynthetic secretory pathway, Science Advances. 2021 Jan 8;7:eaba7803.

6. Hongyu Li#, Zeming Wu#, Xiaoqian Liu#, Sheng Zhang, Qianzhao Ji, Xiaoyu Jiang, Zunpeng Liu, Si Wang, Jing Qu, Weiqi Zhang, Moshi Song*, Eli Song*, Guang-Hui Liu*, ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells, Protein Cell. 2020 Sep;11(9):688-695.

7. Kangmin He#, Eli Song#, Srigokul Upadhyayula#, Song Dang, Raphael Gaudin, Wesley Skillern, Kevin Bu, Benjamin R Capraro, Iris Rapoport, Ilja Kusters, Minghe Ma, Tom Kirchhausen*, Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic, Journal of Cell Biology. 2020 Mar 2;219(3):e201908142.

(Recommended by F1000Prime)

8. Kuan-Chen Lu#, Yujing Zhang#, Eli Song*, Extracellular RNA: mechanisms of it's transporting into target cells, ExRNA. 2019 Volume 1, Article number: 22.

9. Xinyu Zhu#, Min Li#, Xiaojun Xu#, Rui Zhang, Xiaofei Zhang, Zhuo Ma, Jingze Lu J, Tao Xu*, Junjie Hou*, Eli Song*, hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells, Protein Cell. 2018 Oct;9(10):896-901.

10. Xinyu Zhu#, Xiaojun Xu#, Kang Du#, Jingze Lu, Eli Song*, I-BAR protein IRSp53 regulates clathrin-independent endocytosis in a biphasic manner, Science Bulletin. 2018;63(3):149-151.

11. Min Li, Wen Du, Maoge Zhou, Li Zheng, Eli Song*, Junjie Hou*, Proteomic analysis of insulin secretory granules in INS-1 cells by protein correlation profiling, Biophysics Reports. 2018;4(6):329-338. (Cover story)

12. Jiajun Fu, Haining Zhang, Wenming Huang, Xinyu Zhu, Yi Sheng, Eli Song*, Tao Xu*, AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans, Biophysics Reports. 2018;4(1):17-24.

13. Kangmin He#,*, Robert Marsland III, Srigokul Upadhyayula, Eli Song, Song Dang, Benjamin R. Capraro, Weiming Wang, Wesley Skillern, Raphael Gaudin, Minghe Ma, Tom Kirchhausen*, Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic, Nature. 2017 Dec 21;552(7685):410-414.

(Recommended by F1000Prime)

14. Wen Du#, Maoge Zhou#, Wei Zhao#, Dongwan Cheng#, Lifen Wang, Jingze Lu, Eli Song, Wei Feng, Yanhong Xue*, Pingyong Xu*, Tao Xu*, HID-1 is required for homotypic fusion of immature secretory granules during maturation, eLife. 2016 Oct 18;5:e18134.

15. Pingping Lv#, Yi Sheng#, Zhenao Zhao, Wei Zhao, Lusheng Gu, Tao Xu*, Eli Song*, Targeted disruption of Rab10 causes early embryonic lethality, Protein Cell. 2015 Jun;6(6):463-467.

16. Yan Chen#, Zhiping Xia#, Lifen Wang#, Yong Yu, Pingsheng Liu, Eli Song*, Tao Xu*, An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells, Biophysics Reports. 2015;1:34-40.

17. Zhiping Xia#, Yan Chen#, Yi Sheng, Yalan Yi, Eli Song*, Tao Xu*, Whole Genome RNAi Screen in C. elegans Identifies CAB-1 as a Novel Regulator of DCV Secretion, Progress in Biochemistry and Biophysics. 2014 Aug;41(8):787-795.

18. Zhengguang Guo#, Eli Song#,*, Sucan Ma, Shijuan Gao, Xiaorong Wang, Chen Shao, Siqi Hu, Lulu Jia, Dexian Zheng, Tao Xu, Youhe Gao*, A Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain Containing E3 Ubiquitin Ligase, Journal of Proteome Research. 2012 Oct 5;11(10):4847-62.

19. Yu Chen#, Yan Wang#, Jinzhong Zhang#, Yongqiang Deng, Li Jiang, Eli Song, Xufeng S. Wu, John A. Hammer, Tao Xu*, Jennifer Lippincott-Schwartz*, Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes, Journal of Cell Biology. 2012 Aug 20;198(4):545-60.

(Recommended by F1000Prime)

20. Lifen Wang#, Yi Zhan#, Eli Song#, Yong Yu, Yaming Jiu, Wen Du, Jingze Lu, Pingsheng Liu1, Pingyong Xu*, Tao Xu*, HID-1 is a peripheral membrane protein primarily associated with the medial- and trans-Golgi apparatus, Protein Cell. 2011 Jan;2(1):74-85.

21. Yong Yu#, Lifen Wang#, Yaming Jiu#, Yi Zhan, Lin Liu, Zhiping Xia, Eli Song, Pingyong Xu*, Tao Xu*, HID-1 is a novel player in the regulation of neuropeptide release, Biochemical Journal. 2011 Mar 15;434(3):383-90.

(Recommended by F1000Prime)

22. Siqi Hu, Eli Song, Rui Tian, Sucan Ma, Tao Yang, Yi Mu, Yuan Li, Chen Shao, Shijuan Gao, Youhe Gao*, Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex, Cellular Physiology and Biochemistry. 2009;24(3-4):231-42.

23. Lulu Jia, Ling Zhang, Chen Shao, Eli Song, Wei Sun, Mingxi Li, Youhe Gao*, An attempt to understand kidney's protein handling function by comparing plasma and urine proteomes, PloS ONE. 2009;4(4):e5146.

24. Sucan Ma#, Eli Song#, Shijuan Gao, Rui Tian, Youhe Gao*,Rapid Characterization of the Binding Property of HtrA2/Omi PDZ Domain by Validation Screening of PDZ Ligand Library, Science in China Series C: Life Sciences. 2007 Jun;50(3):412-22.

25. Eli Song#, Shijuan Gao#, Rui tian#, Sucan Ma, Haiming Huang, Jiayan Guo, Yingna Li, Ling Zhang, Youhe Gao*, A High-Efficiency Strategy for Binding Property Characterization of Peptide Binding Domains, Molecular & Cellular Proteomics. 2006 Aug;5(8):1368-81.

26. Eli Song#,*, Life Science and Biotechnology in China, Bio-science Law Review. 2006;7(6):224-228.

出版论著:

1. 宋婀莉、高友鹤,《人体病理生理学》(第3版),人民卫生出版社,第二篇第5章《蛋白质-蛋白质相互作用与疾病》

2. 徐涛、宋婀莉、张蓉颖,《分子细胞生物学》(第3版),高等教育出版社,第5章《细胞囊泡运输》

3. Liangyi Chen and Eli Song. Molecular Imaging-Fundamentals and Applications (Springer Press), Part III, Chapter 18, Using molecular imaging techniques to study protein-protein interactions

发明专利:

1. 发明名称:一种验证性筛选目的结构域结合配体的方法,发明人:高友鹤,宋婀莉,高诗娟,田瑞,马素参,黄海明,专利号:ZL.200610057182.1

(资料来源:宋婀莉研究员,2021-12-08)